There are three main ways to enter and exit Rurrenabaque.Buses travel south to La Paz from the bus terminal on a daily basis, usually leaving around 10AM. It is wise to purchase tickets at least a day in advance. The price is approximately $US10 and the journey to La Paz, stopping at Caranavi and Corico can take over a day depending on weather conditions. It is advisable to take food and water supplies, although meal stops do take place.
The more expensive $US50-$US80 way to enter or exit Rurrenabaque is by flying. There are two airlines both of which have ticket offices in Rurrenabaque town center. The airlines are Amazonas, which operates numerous daily flights, and TAM, who have one to three flights weekly.TAM, run by the Bolivian military, operates slightly larger planes and are on the cheaper end of the scale, where as Amazonas tend to be slightly more expensive but more regular. The flight to La Paz takes between 40 minutes and 55 minutes.
It is worth noting that various atmospheric conditions often lead to the delay of flights, including smoke from forest burning, low cloud cover and heavy rain which saturates the grass runway. Services are more reliable out of the rainy season.